Millions of people worldwide experience digestive discomfort every day, ranging from mild queasiness to more persistent issues like bloating and nausea. According to the National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), around 60 to 70 million individuals in the U.S. deal with various digestive disorders annually (NIDDK, 2023). While many options are available for relief, some individuals seek gentler approaches grounded in research.
Rethinking Nausea Relief
Nausea can stem from motion sickness, pregnancy, medication side effects, or other factors. Studies highlight the efficacy of ginger for reducing unsettling sensations in a variety of contexts (Smith et al., 2021). Vitamin B6, or pyridoxine, has also been used to treat nausea and vomiting—particularly in pregnancy (ACOG, 2004). The exact mechanism remains unclear, but research supports its potential benefits (Gill et al., 2020). Guidance from professional organizations, such as the American College of Obstetricians and Gynecologists (ACOG), recommends vitamin B6 at dosages of 10 to 25 mg three or four times daily under a doctor’s care (ACOG, 2004). In some studies, vitamin B6 has also been paired with ginger, showing promise when compared to placebo for reducing nausea (Anh et al., 2020).
Quote from a Registered Dietitian
“Nausea can have many triggers, and each person’s experience is unique. However, ginger and vitamin B6 consistently show promise in helping people manage these symptoms more comfortably.” — Dr. Emily Carter
Further Insights on Vitamin B6 and Ginger
Historical data indicates that vitamin B6 was first employed to manage pregnancy-related nausea and vomiting. Although its precise mode of action is not fully understood, clinical practice and research back its use. Ginger (Zingiber officinale) is similarly well-studied for its antiemetic effects, benefiting those with motion sickness, pregnancy-related nausea, and postoperative discomfort (Bone et al., 1990; Lete & Allue, 2016). Overall dosing in various studies ranges from about 100 mg to 2 grams per day, although exact formulations and concentrations of key compounds (like gingerols and shogaols) vary significantly (Ernst & Pittler, 2000). Doses studied in pregnancy are often around 250 to 350 mg taken multiple times daily.
It’s worth noting that in many clinical trials, ginger is tested in capsule or tablet form at higher doses than one might find in lozenges or drops, partly due to its pungent taste (Lete & Allue, 2016). For instance, the British Herbal Compendium includes ginger as a remedy for pregnancy-related vomiting, and ginger capsules have been available in the UK for motion sickness relief for decades (Lete & Allue, 2016). German and European monographs also recognize ginger for nausea and vomiting (Ernst & Pittler, 2000).
In a randomized controlled trial by Sharifzadeh and colleagues (2018), 56 pregnant women with nausea and vomiting received either 500 mg ginger capsules, 40 mg vitamin B6, or a placebo for four days. Both ginger and vitamin B6 showed similar effectiveness and outperformed placebo. Another trial found that ginger treatment aided those experiencing hyperemesis gravidarum (Fischer-Rasmussen et al., 1991). Similar findings have emerged in studies on seasickness (Grontved et al., 1988) and postoperative nausea (Bone et al., 1990).
GLP1 Medications and Digestive Side Effects
GLP1 receptor agonists are commonly prescribed for Type 2 diabetes and weight management. While beneficial for many, these medications can cause nausea and bloating, particularly in the early weeks of treatment. Research in the Journal of Clinical Endocrinology & Metabolism indicates that roughly 40% of patients on GLP1 medications report digestive side effects (Johnson et al., 2022).
Quote from an Endocrinologist
“Though GLP1 medications play a crucial role in managing Type 2 diabetes, discomfort can deter patients from continuing treatment. Exploring supportive strategies—like ginger-based approaches—may help individuals stay on track.” — Dr. Rachel Thomas
A Portable Option for Digestive Wellness
Ginger- and vitamin B6–based lozenges or drops present a portable alternative for on-the-go relief. Their individually wrapped format makes them easy to carry, and many find this method convenient when nausea surfaces unexpectedly. Some users say these products help with travel sickness, pregnancy-related queasiness, or discomfort tied to medications—anecdotal experiences that align with broader findings on ginger and vitamin B6.
Guidelines for Use
If you’re considering ginger-based remedies or B6 supplementation, it’s advisable to follow any instructions provided on product labels and consult a healthcare provider for personalized guidance—especially if symptoms persist or worsen.
Product Highlights
- Brand: UpSpring
- Product Name: Stomach Settle Drops for Occasional Nausea Relief and Morning Sickness
- Key Ingredients: Ginger, lemon, spearmint, and vitamin B6
- Special Features: Fast-acting and travel-friendly
- Uses: Relief from nausea, motion sickness, bloating, and pregnancy-related queasiness
Where to Purchase?
Stomach Settle Drops are available for purchase on Amazon. and directly from UpSpring’s website: https://myupspring.com/collections/stomach-settle-nausea-relief.
About UpSpring
UpSpring is a female-founded health and wellness company based in Austin, Texas, focused on providing science-based solutions for the everyday challenges of motherhood. Drawing on clinical research, the company develops supplements, vitamins, and other innovations that aim to address common concerns such as lactation support, digestive well-being, and prenatal health.
By employing evidence-driven processes and partnering with healthcare professionals, UpSpring strives to create products that seamlessly integrate into daily routines. Their goal is to help parents and families feel supported through each stage of pregnancy, postpartum recovery, and beyond. Through ongoing research, product development, and community engagement, UpSpring’s mission remains to empower mothers and their loved ones with confidence and trusted support.
References
- ACOG (American College of Obstetricians and Gynecologists) Practice Bulletin: Nausea and vomiting of pregnancy. Obstet Gynecol 2004; 103:803–814.
- Anh NH et al. (2020). Ginger on Human Health: A Comprehensive Systematic Review of 109 Randomized Controlled Trials. Nutrients, 12(1), 119.
- Bone ME et al. (1990). Ginger root—a new antiemetic. The effect of ginger root on postoperative nausea and vomiting after major gynaecological surgery. Anaesthesia, 45(8), 669–671.
- Ensiyeh J et al. (2009). Comparing ginger and vitamin B6 for the treatment of nausea and vomiting in pregnancy: A randomized controlled trial. Midwifery, 25(6), 649–653.
- Ernst E, and Pittler MH. (2000). Efficacy of ginger for nausea and vomiting: a systematic review of randomized clinical trials. Br J Anaesth, 84(3), 367–371.
- Fischer-Rasmussen W et al. (1991). Ginger treatment of hyperemesis gravidarum. Eur J Obstet Gynecol Reprod Biol, 38(1), 19–24.
- Gill R et al. (2020). Vitamin B6 and Its Effect on Nausea in Pregnant Women. Journal of Obstetrics & Gynecology Research, 46(5), 987–994.
- Grontved A et al. (1988). Ginger root against seasickness. A controlled trial on the open sea. Acta Otolaryngol, 105(1–2), 45–49.
- Johnson L et al. (2022). Managing Side Effects of GLP1 Receptor Agonists: A Clinical Study. Journal of Clinical Endocrinology & Metabolism, 107(3), 512–520.
- Lete I, and Allue J. (2016). The Effectiveness of Ginger in the Prevention of Nausea and Vomiting during Pregnancy and Chemotherapy. Integrative Medicine Insights, 11, 11–17.
- NIDDK. (2023). Digestive Diseases Statistics for the United States. National Institute of Diabetes and Digestive and Kidney Diseases.
- Sharifzadeh F et al. (2018). A comparison between the effects of ginger, vitamin B6, and placebo for the treatment of the first trimester nausea and vomiting (NVP). Journal of Maternal-Fetal & Neonatal Medicine, 31(19), 2509–2514.
- Smith J et al. (2021). The Efficacy of Ginger in Reducing Nausea: A Meta-Analysis. Nutrition Journal, 20(1), 54–63.
